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In recent years, anaerobic bacteria have shown a rise in antimicrobial resistance (AMR), leading to the emergence of resistant strains - sometimes described as “superbugs”. This development has made it much harder to treat infections effectively, posing a global challenge. We offer a wide range of products, some of which can be used to contribute to this field of research. In this article, we focus on the Whitley A35 Anaerobic Workstation.
Characterisation of food chain C. difficile isolates in Ireland
A study conducted in Ireland by Marcos et al. titled ‘Characterization of Food Chain Clostridioides difficile Isolates in Terms of Ribotype and Antimicrobial Resistance’ utilised the Whitley A35 Anaerobic Workstation to maintain these isolates and to perform Minimum Inhibitory Concentration (MIC) testing using the E-test method. The aim of this study was to characterise C. difficile isolates from the farm, abattoir, and retail outlets in Ireland in terms of ribotype and antibiotic resistance.
C. difficile as a drug target for microbiome-sparing antibiotics
The Whitley A35 Anaerobic Workstation was used in a recent study by Dureja et al., ‘In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy’. This research investigated C. difficile enoyl ACP reductase (CdFabK), a crucial enzyme in de novo fatty acid synthesis, as a drug target for microbiome-sparing antibiotics. C. difficile R20291 was used as a control strain throughout the study, and all bacterial strains were grown at 37 °C in the Whitley A35 Workstation.
Antimicrobial Susceptibility of Bifidobacterium pseudocatenulatum in Vietnam
In a study by Chung The et al. titled ‘Exploring the Genomic Diversity and Antimicrobial Susceptibility of Bifidobacterium pseudocatenulatum in a Vietnamese Population’ the Whitley A35 Anaerobic Workstation played a role in the culturing and identifying the anaerobic bacteria, Bifidobacterium. This applied to all samples that attributed to Bifidobacterium pseudocatenulatum above 0.1% of total sequenced reads (7 adults, 9 children). This paper provides a wider understanding of the anaerobic bacteria in Vietnam and its genomic diversity, metabolic potential, and antimicrobial susceptibility.
We are delighted to see the Whitley A35 Anaerobic Workstation being used to support the ongoing research into AMR, a crucial area of research and gateway to a broad spectrum of studies. For more information on our Anaerobic Workstation range please see the products below or if you're interested in reading more scientific papers, please visit our Published Papers database.
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